Fellowships and Publications outcomes

BTP Students who have completed their Ph.D. have an average of 3.5 publications, with 1.3 first-author publications. Of the 54 Ph.D.-holding alumni from the trailing decade.

Recent Patents and Publcations

Patents
Patent: U.S. Provisional Application No.: 62/578,730 Title: LAYER-BY-LAYER NANOPARTICLES FOR CYTOKINE THERAPY IN CANCER TREATMENT Inventors: Antonio Eric Barberio et al.

PATENT: Provisional Patent Application NO.: 62/577,867, Title: METHODS AND COMPOSITIONS FOR PERFORMING CONTINUOUS DIRECTEDC EVOLUTION, Inventors: Matthew D. Shoulders, Chet Berman, Christopher L. Moore, Louis J. Papa, Samuel J. Hendel

Publications
Valdez J, Cook CD, Ahrens CC, Wang AJ, Brown A, Kumar M, Stockdale L, Rothenberg D, Renggli K, Gordon E, Lauffenburger DL, White F, Griffith L. On-demand dissolution of modular-synthetic extracellular matrix reveals local epithelial-stromal communication networks. Biomaterials. 2017 PMCID:PMC5461961

Hsu, T. M., Welner, D. H., Russ, Z. N., Cervantes, B., Prathuri, R. L., Adams, P. D., & Dueber, J. E. (2018). Employing a biochemical protecting group for a sustainable indigo dyeing strategy. Nature Chemical Biology. https://doi.org/10.1038/nchembio.2552 PMID: 29309053

Zhu, W.; Easthon, L. M.; Reinhardt, L. A.; Tu, C.; Cohen, S. E.; Silverman, D. N.; Allen, K. N.; Richards, N. G. J. (2016) Substrate binding mode and molecular basis of a specificity switch in oxalate decarboxylase. Biochemistry. 55: 2163-2173. PMCID: PMC4854488

KR Love, NC Dalvie, and JC Love. “The yeast stands alone: the future of protein biologic production.” Current Opinion in Biotechnology. 2017 Dec 22, 53:50-58. doi: 10.1016/j.copbio.2017.12.010. PMID: 29277062

AKD Younger, NC Dalvie, AG Rottinghaus, and JN Leonard. “Engineering novel modular biosensors to confer metabolite-responsive regulation of transcription.” ACS Synthetic Biology. 2016 October 17, 6 (2):311-325. doi: 10.1021/acssynbio.6b00184. PMID: 27744683

Jorgensen H, Hill A., Beste M., Kumar M.P.… Lauffenburger D.A.,Griffith L.G., Qvigstad E. (2017). “Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility” (In Press) Fertility and Sterility.

Valdez, J.L., Cook C.,Chopko C., Wang A.J., Brown A.T., Kumar, M.P.,…Griffith L.G. (2016) Local epithelial-stromal communication in 3D revealed by on-demand dissolution of synthetic, modular, extracellular matrix. (Submitted)

Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase Marco Biancucci, Amy E. Rabideau, Zeyu Lu, Alex R. Loftis, Bradley L. Pentelute, and Karla J. F. Satchell Biochemistry 2017 56 (21), 2747-2757 DOI: 10.1021/acs.biochem.7b00246 PMC5626579

BH Kwan, EF Zhu, A Tzeng, HR Sugito, AA Eltahir, B Ma, MK Delaney, PA Murphy, MJ Kauke, A Angelini, N Momin, NK Mehta, AM Maragh, RO Hynes, G Dranoff, JR Cochran, KD Wittrup. Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. JEM, 2016. 6, 1679-1690. PMCID: PMC5460993

KD Moynihan, CF Opel, GL Szeto, A Tzeng, EF Zhu, JM Engreitz, RT Williams, K Rakhra, MH Zhang, AM Rothschilds, S Kumari, RL Kelly, BH Kwan, W Abraham, K Hu, NK Mehta, MJ Kauke, H Suh, JR Cochran, DA Lauffenburger, KD Wittrup, DJ Irvine. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nature Medicine, 2016. 22, 1402-1410. PMCID: PMC5209798

A Tzeng, MJ Kauke, EF Zhu, KD Moynihan, CF Opel, NJ Yang, N Mehta, RL Kelly, GL Szeto, WW Overwijk, DJ Irvine, KD Wittrup. Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy. Cell Reports, 2016. 17, 2503-2511. PMCID: PMC5204262

MW Traxlmayr, JD Kiefer, RR. Srinivas, E Lobner, AW Tisdale, NK Mehta, NJ Yang, B Tidor, KD Wittrup. Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-Neutralized Hyperthermostable Sso7d Scaffold Library. Journal of Biological Chemistry, 2016. PMCID: PMC5077188

Milling, L., Zhang, Y., & Irvine, D. J. (2017). Delivering safer immunotherapies for cancer. Advanced Drug Delivery Reviews. PMCID: PMC5647831

Kaylan, K. B., Gentile, S. D., Milling, L. E., Bhinge, K. N., Kosari, F., & Underhill, G. H. (2016). Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays. Integrative Biology, 8(12), 1221-1231.

Kwan, B.; Zhu, E,; Tzeng, A.; Sugito, H.; Eltahir, A.; Ma, B.; Delaney, M.; Murphy, P.; Kauke, M.; Angelini, A.; Momin, N.; Mehta, N.; Maragh, A.; Hynes, R.; Dranoff, G.; Cochran, J.; Wittrup, K. D. Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. Journal of Experimental Medicine. 2017 PMCID: PMC5460993

Nagarajan MB, Tentori, AM, Zhang WC, Slack FJ, Doyle PD (in preparation). “Non-fouling, encoded hydrogel particles for multiplex microRNA profiling directly from formalin-fixed, paraffin embedded tissue.”

J. Valdez, C. Cook, C.C. Ahrens, A.J. Wang, A.T. Brown, M. Kumar, L. Stockdale, D. Rothenberg, K. Renggli, E. Gordon, D.A. Lauffenburger, F. White, L.G. Griffith. “On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks.” Biomaterials, June 2017. PMCID: PMC5461961

C.M. Horejs, J.P. St-Pierre, J.R. Ojala, J. Steele, P. da Silva, A. Rynne-Vidal, S. Maynard, C. Hansel, C. Rodriguez-Fernandez, M.M. Mazo, A.Y. You, A.J. Wang, T. Erlach, K. Tryggvason, M. Lopez-Cabrera, M.M. Stevens. “Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information.” Nature Communications, June 2017. PMCID:
PMC5472175

The MIT BTP would like to highlight Professor Jennifer Cochran
PI of the Stanford Biotechnology Training Program
(http://cochranlab.net)

Avery, Reginald
Lemelson Engineering Presidential Fellowship (2012)
Best Poster Award Nominee, Materials Research Society Fall Meeting, Dec 1-6, 2013

Berman, Chet
Masamune Memorial Fund Fellowship (2015)
Daniel C. Kemp Graduate Fellowship (2015)
Robert T. Haslam Presidential Fellowship (2015)

Cook, Christi – N/A
Biotechnology Training Program, Best Poster Award, May 2015 annual retreat

Kedaigle, Amanda
Acceptance to Graduate Education in Medical Sciences program at MIT
Wellesley College Jerome E. Schiff fellowship for honors thesis work (undergrad)

Doong, Stephanie
Synberc Fall Retreat 2nd Place Poster Award
Terman Engineering Scholastic Award (Stanford)
Mason-Marsden Prize in Chemical Engineering Research (Stanford)

Guay, Lisa
NSF Graduate Research Fellowship – May 2015
Fellowships: Wellesley College Jerome E. Schiff fellowship for honors thesis work (undergrad),
Honors to Date:
Synberc Fall 2015 Conference – Honorable Mention Poster Award

Kelly, Ryan
UCLA Chemical & Biomolecular Engineering Department Outstanding BS Award (2012)
NSF Graduate Research Fellowship Honorable Mention (2013, 2012)
UCLA Distinguished Senior Award (2011)

Mehta, Naveen
NSF GRFP, BTP

Rothschilds, Adrienne
NSF Graduate Research Fellowship Program, NIH Biotechnology Training Program

Stevens, Mark
Merck Index Award (Top three graduating seniors, based on Faculty Nomination), 2008
College Honors, 2008
Mary Gates Research Scholarship (Based on Research Proposal), 2006 – 2007, 2007 – 2008
International Programs and Exchanges Travel Scholarship, 2007
Arts & Science Undergraduate Research Award (Based on Research Proposal), 2006
UW Dean’s List, 2005 – 2007
UW Undergraduate Scholar Award Recipient, 2004 – 2006

Wang, Stephanie
MIT Department of Biological Engineering Viterbi Graduate Fellowship, 2014
Honors to Date:
UCLA Dean’s Prize for Research (Science Poster Day), 2014
UCLA HSSEAS Faculty Fund Scholarship, 2014
UCLA Senior Undergraduate Research Scholarship, 2013
UCLA Amgen Scholars Program, 2013
UCLA HSSEAS Alfred C. Ingersoll Scholarship, 2013
UCLA HSSEAS Kwon Family Undergraduate Scholarship, 2012
Dean’s Honors List, 2011 – 2014
Robert C. Byrd Scholarship, 2010

Wang, Alex
2014-2015: Viterbi Graduate Fellowship
2013-2014: US-UK Fulbright – Imperial College Postgraduate Award
2013: Tau Beta Pi
2012: Summer Undergraduate Research Fellowship – Richter Scholar
2011: Summer Undergraduate Research Fellowship

Wittenborn, Elizabeth
Robert T. Haslam Presidential Fellowship, 2012-2013